Members

Jacob Scott

Alexander R. A. Anderson

Contact: 813-745-6119, alexander.anderson@moffitt.org
Web: http://labpages.moffitt.org/andersona/
Research Interests: Cancer invasion, evolutionary dynamics, angiogenesis, individual based models, spatial models, multiscale models, tumour microenvironment

Recent/relevant publication list:

1. Anderson AR, Hassanein M, Branch KM, Lu J, Lobdell NA, Maier J, Basanta D, Weidow B, Narasanna A, Arteaga CL, Reynolds AB, Quaranta V, Estrada L, Weaver AM. Microenvironmental independence associated with tumor progression. Cancer Res. 2009 Nov 15;69(22):8797-806.
2. Enderling H, Anderson AR, Chaplain MA, Beheshti A, Hlatky L, Hahnfeldt P. Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics. Cancer Res. 2009 Nov 15;69(22):8814-21.
3. Basanta D, Strand DW, Lukner RB, Franco OE, Cliffel DE, Ayala GE, Hayward SW, Anderson AR. The role of transforming growth factor-beta-mediated tumor-stroma interactions in prostate cancer progression: an integrative approach. Cancer Res. 2009 Sep 1;69(17):7111-20.
4. Hinow P, Gerlee P, McCawley LJ, Quaranta V, Ciobanu M, Wang S, Graham JM, Ayati BP, Claridge J, Swanson KR, Loveless M, Anderson AR. A spatial model of tumor-host interaction: application of chemotherapy. Math Biosci Eng. 2009 Jul;6(3):521-46.
5. Ramis-Conde I, Chaplain MA, Anderson AR, Drasdo D. Multi-scale modelling of cancer cell intravasation: the role of cadherins in metastasis. Phys Biol. 2009 Mar 25;6(1):16008.
6. Gerlee P. & Anderson A. R. A. Evolution of cell motility in an individual-based model of tumour growth. J Theor Biol. 2009 Jul 7;259(1):67-83.
7. Anderson, A. R. A. & Quaranta, V. (2008) “Integrative Mathematical Oncology”, Nature Rev. Cancer, 8, 227-234

David Basanta

1. Basanta D, Strand DW, Lukner RB, Franco OE, Cliffel DE, Ayala GE, Hayward SW, Anderson AR. The role of transforming growth factor-beta-mediated tumor-stroma interactions in prostate cancer progression: an integrative approach. Cancer Res. 2009 Sep 1;69(17):7111-20.
2. A game theoretical perspective on the somaticevolution of cancer. Chapter in In Selected topics on cancer modelling: genesis, evolution, inmune competition, therapy (N. Bellomo, M. Chaplain and E. De Angelis Eds.). Birkhauser, Boston.
3. Evolutionary game theory elucidates the role of glycolysis in glioma progression and invasion. D. Basanta, M. Simon, H. Hatzikirou and A. Deutsch. Cell Proliferation 41 (6) 980. 2008.
4. A game theoretical study of evolution of invasion in tumours. D. Basanta, H. Hatzikirou and A. Deutsch. Eur. Phys. Journal B 2008.
5. Robust homeostasis and wound healing in evolved artificial multicellular organisms. Basanta D, Miodownik M, Baum B (2008) The Evolution of Robust Development and Homeostasis in Artificial Organisms. PLoS Comput Biol 4(3): e1000030. doi:10.1371/journal.pcbi.1000030

Edward Flach

Jill Gallaher

Bob Gatenby

1. Fang J, Gillies RJ, Gatenby RA Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Seminars in Cancer Biology, 2008.
2. Gillies RJ, Robey I, Gatenby RA Causes and consequences of increased glucose metabolism of cancers. Journal of Nuclear Medicine 49(2):24S-42S, 2008.
3. Gatenby RA, Gillies RJ. A microenvironmental model of carcinogenesis. Nat Rev Cancer. 8(1):56-61, Jan 2008.
4. Huang L, Lai Y-C, Gatenby RA Alternating synchronizability of complex clustered networks with regular local structure. Phys Rev E Stat Nonlin Soft Matter Phys. 77:016103, 2008.
5. Moellering RE, Black KC, Krishnamurty C, Baggett BK, Stafford P, Rain M, Gatenby RA, Gillies RJ. Acid treatment of melanoma cells selects for invasive phenotypes. Clin Exp Metastasis. 25(4):411-25, 2008.
6. Vincent TL, Gatenby RA An evolutionary model for initiation, promotion, and progression in carcinogenesis. International Journal of Oncology. 32:729-737, 2008.
7. Frieden BR, Gatenby RA. Equations of Biological Population Growth from Hartree Scattering. Accepted Physical Review E.
8. Vincent, TL, Gatenby, RA, Somatic evolution of cancer. International Game Theory Review. 10(1): 101-118, 2008.
9. Gatenby RA, Frieden BR. Inducing catastrophe in malignant growth. Mathematical Medicine & Biology. 2008.
10. Smallbone K, Gatenby RA, Maini PK. Mathematical modeling of tumor acidity. Accepted to Journal of Theoretical Biology. 2008.
11. Robey IF, Stephen RM, Brown KS, Baggett BK, Gatenby RA, Gillies RJ. Regulation of the Warburg effect in early-passage breast cancer cells. Neoplasia. 10(8):745-56, 2008.
12. Fang JS, Gillies RD, Gatenby RA. Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Seminars in Cancer Biology. 18:330-337, 2008.
13. Gillies RJ, Robey I, Gatenby RA. Causes and consequences of increased glucose metabolism of cancer. J Nucl Med. 2:24S-42S, 2008

Eunjung Kim

Dave Morse

1. Morse DL, Galons J-P, Payne C, Jennings D, Day Sam, Xia G, Gillies RJ. MRI-measured water mobility increases in response to chemotherapy via multiple cell-death mechanisms. NMR Biomed. 2007; 20: 602-614.
2. Morse DL, Raghunand N, Sadarangani P, Murthi S, Job C, Day S, Howison C, Gillies RJ. Response of choline metabolites to docetaxel therapy is quantified in vivo by localized 31P MRS of human breast cancer xenografts and in vitro by high-resolution 31P NMR spectroscopy of cell extracts. Magn Reson Med. 2007; 58(2): 270-80.
3. Vagner J, Xu L, Handl HL, Josan JS, Morse DL, Mash EA, Gillies RJ, Hruby VJ. Heterobivalent Ligands Crosslink Multiple Cell-Surface Receptors: The Human Melanocortin-4 and delta-Opioid Receptors. Angew Chem Int Ed Engl. 2008; 47(9): 1685-8.
4. Han H, Gillies RJ, Morse DL, Hruby VJ. Patent: Method of Identifying Pancreatic Cancer Cells. 2008.
5. Balagurunathan Y, Morse DL, Hostetter G, Shanmugam V, Stafford P, Shack S, Pearson J, Trissal M, Demeure MJ, Von Hoff DD, Hruby VJ, Gillies RJ, Han H. Gene expression profiling-based identification of cell-surface targets for developing multimeric ligands in pancreatic cancer. Mol Cancer Ther. 2008; 7(9): 3071-80.
6. Morse DL, Carroll D, Day S, Gray H, Sadarangani P, Murthi S, Job C, Baggett B, Raghunand N, Gillies RJ. Characterization of breast cancers and therapy response by MRS and quantitative gene expression profiling in the choline pathway. NMR Biomed. 2008 (in press).

Katarzyna A. Rejniak

1. Rejniak K.A., S.E. Wang, N.S. Bryce, H. Chang, B. Parvin, J. Jourquin, L. Estrada, J.W. Gray, C.L. Arteaga, A.M. Weaver, V. Quaranta, A.R.A. Anderson, Linking Changes in Epithelial Morphogenesis to Cancer Mutations Using Computational Modeling, PLoS Computational Biology, 2010, 6(8):e1000900
2. Rejniak K.A., A.R.A. Anderson, Multiscale hybrid models of tumor growth, Wiley Interdisciplinary Reviews: System Biology and Medicine, in press
3. Rejniak K.A., McCawley L.J., Current trends in mathematical modeling of tumor-microenvironment interactions: a survey of tool and applications, Experimental biology and Medicine, 235:411-423, 2010 
4. Anderson, A.R.A., Rejniak, K.A., Gerlee, P., Quaranta, V., Microenvironment driven invasion: a multiscale multimodel investigation, Journal of Mathematical Biology, 58:579-624, 2009
5. Quaranta, V., Rejniak, K.A., Gerlee, P., Anderson, A.R.A, Invasion emerges from cancer cell adaptation to competitive microenvironments: Quantitative predictions from multiscale mathematical models., Seminars in Cancer Biology, 18:338-348, 2008
6. Rejniak, K.A., Anderson, A.R.A, A computational study of the development of epithelial acini. I. Sufficient conditions for the formation of a hollow structure, Bulletin of Mathematical Biology, 70(3):677–712, 2008
7. Rejniak, K.A., Anderson, A.R.A., A computational study of the development of epithelial acini. II. Necessary conditions for structure and lumen stability, Bulletin of Mathematical Biology, 70(5):1450–1479, 2008
8. Anderson, A.R.A, Rejniak, K.A., Gerlee, P., Quaranta, V., Modelling of cancer growth, evolution and invasion: bridging scales and models, Mathematical Modelling of Natural Phenomena, 2(3):1-29, 2007

Mark Robertson-Tessi

Jacob Scott

Ariosto Silva

Recent/relevant publication list: 

1. Assump??o JG, Ganazza MA, de Ara?jo M, Silva AS, Scrideli CA, Brandalise SR, Yunes JA. Detection of clonal immunoglobulin and T-cell receptor gene rearrangements in childhood acute lymphoblastic leukemia using a low-cost PCR strategy. Pediatr Blood Cancer. 2010 Dec;55(7):1278-1286. Pubmedid: 20730889.   Pubmed ID: 20730889
2. Silva AS, Gatenby RA, Gillies RJ, Yunes JA. A quantitative theoretical model for the development of malignancy in ductal carcinoma in situ. J Theor Biol. 2010 Feb;262(4):601-613. Pubmedid: 19887072.   Pubmed ID: 19887072
3. Silva AS, Gatenby RA. A theoretical quantitative model for evolution of cancer chemotherapy resistance. Biol Direct. 2010;5:25. Pubmedid: 20406443. Pmcid: PMC2868834.   Pubmed ID: 20406443
4. Gatenby RA, Silva AS, Gillies RJ, Frieden BR. Adaptive therapy. Cancer Res. 2009 Jun;69(11):4894-4903. Pubmedid: 19487300.   Pubmed ID: 19487300
5. Silva AS, Yunes JA, Gillies RJ, Gatenby RA. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res. 2009 Mar;69(6):2677-2684. Pubmedid: 19276380.   Pubmed ID: 19276380
6. Rodrigues AS, Matos CB, Silva F, Fonseca I, Nogueira C, Santos J, Silva AS, Cabrita A. Long-term peritoneal dialysis experience in Portugal. Int J Artif Organs. 2006 Dec;29(12):1109-1116. Pubmedid: 17219350.   Pubmed ID: 17219350
7. Silva AS, Yunes JA. Conservation of glycolytic oscillations in Saccharomyces cerevisiae and human pancreatic beta-cells: a study of metabolic robustness. Genet Mol Res. 2006;5(3):525-535. Pubmedid: 17117368.   Pubmed ID: 17117368