Mark L. McLaughlin, PhD

The McLaughlin group focuses on the de novo design and synthesis of molecules designed to inhibit alpha-helix-like and beta-sheet-like protein-protein interactions.  Our lab has used several different repetitive scaffolds to structurally mimic the i, i + 4, and i + 7 side chains of an alpha-helix to develop more drug-like protein-protein interaction inhibitors.

• Drake BL, Morris JL, McLaughlin ML, Fronczek FR, Watkins SF. Tetra-methyl anthracene-2,3,6,7-tetra-carboxyl-ate-tetra-methyl 9,10-dihydro-9,10-dioxoanthracene-2,3,6,7-tetra-carboxyl-ate (1/1). Acta Crystallogr Sect E Struct Rep Online. 2012 Aug;68(Pt 8):o2540-o2541. Pubmedid: 22904973. Pmcid: PMC3414986.
• McLaughlin M, Belyk KM, Qian G, Reamer RA, Chen CY. Synthesis of α-Hydroxyacetophenones. J Org Chem. 2012 Jun;77(11):5144-5148. Pubmedid: 22568765.
• Zhong YL, Gauthier DR, Shi YJ, McLaughlin M, Chung JY, Dagneau P, Marcune B, Krska SW, Ball RG, Reamer RA, Yasuda N. Synthesis of antifungal glucan synthase inhibitors from enfumafungin. J Org Chem. 2012 Apr;77(7):3297-3310. Pubmedid: 22423625.
• Cutler CS, Chanda N, Shukla R, Sisay N, Cantorias M, Zambre A, McLaughlin M, Kelsey J, Upenandran A, Robertson D, Deutscher S, Kannan R, Katti K. Nanoparticles and phage display selected peptides for imaging and therapy of cancer. Recent Results Cancer Res. 2012;194:133-147. Pubmedid: 22918758.
• Emmons MF, Gebhard AW, Nair RR, Baz R, McLaughlin ML, Cress AE, Hazlehurst LA. Acquisition of resistance toward HYD1 correlates with a reduction in cleaved α4 integrin expression and a compromised CAM-DR phenotype. Mol Cancer Ther. 2011 Dec;10(12):2257-2266. Pubmedid: 21980133. Pmcid: PMC3237739.
• Phelan WA, Ngu-Schwemlein M, Fronczek FR, McLaughlin ML, Watkins SF. 1,2-Dihydro-9H-carbazole-4(3H)-thione. Acta Crystallogr Sect E Struct Rep Online. 2011 Apr;67(Pt 4):o757. Pubmedid: 21754054. Pmcid: PMC3099987.
• Anderson L, Zhou M, Sharma V, McLaughlin JM, Santiago DN, Fronczek FR, Guida WC, McLaughlin ML. Facile iterative synthesis of 2,5-terpyrimidinylenes as nonpeptidic alpha-helical mimics. J Org Chem. 2010 Jun;75(12):4288-4291. Pubmedid: 20469918. Pmcid: PMC2901110.
• Sharma V, McLaughlin ML. Efficient assembly of 2,5,6-substituted pyrimidines via MgI(2)-mediated Morita-Baylis-Hillman reaction. J Comb Chem. 2010 May;12(3):327-331. Pubmedid: 20218627. Pmcid: PMC2919067.
• Fronczek CF, Kil H, McLaughlin ML, Fronczek FR. (S)-(Z)-Methyl 2-[2,3-bis-(benzyl-oxy-carbon-yl)guanidino]-4-methyl-penta-no-ate. Acta Crystallogr Sect E Struct Rep Online. 2010;67(Pt 1):o27-o28. Pubmedid: 21522740. Pmcid: PMC3050400.
• Xu Y, McLaughlin M, Chen CY, Reamer RA, Dormer PG, Davies IW. A general method for the synthesis of 3,5-diarylcyclopentenones via friedel-crafts acylation of vinyl chlorides. J Org Chem. 2009 Jul;74(14):5100-5103. Pubmedid: 19485346.
• Lawrence HR, Li Z, Yip ML, Sung SS, Lawrence NJ, McLaughlin ML, McManus GJ, Zaworotko MJ, Sebti SM, Chen J, Guida WC. Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking. Bioorg Med Chem Lett. 2009 Jul;19(14):3756-3759. Pubmedid: 19457663. Pmcid: PMC2754843.
• Kazi A, Lawrence H, Guida WC, McLaughlin ML, Springett GM, Berndt N, Yip RM, Sebti SM. Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells. Cell Cycle. 2009 Jun;8(12):1940-1951. Pubmedid: 19471122. Pmcid: PMC2892826.
• Yi SW, Jain P, Ajmera M, Kaulagari SR, Topper M, Anderson L, McLaughlin ML. Cysteine based PNA (CPNA): design and synthesis of novel CPNA monomers. Adv Exp Med Biol. 2009;611:553-554. Pubmedid: 19400310.
• Anderson L, Topper M, Jain P, McIntosh E, McLaughlin ML. Synthesis of N-Boc protected hydrazine diacids as key structural units for the formation of alpha-helix mimics. Adv Exp Med Biol. 2009;611:211-212. Pubmedid: 19400164.
• Mokdad A, Belof J, Yi S, Shuler S, McLaughlin M, Space B, Larsen R. Photophysical studies of the trans to cis isomerization of the push-pull molecule: 1-(pyridin-4-yl)-2-(N-methylpyrrol-2-yl)ethene (mepepy). J Phys Chem A. 2008 Sep;112(36):8310-8315. Pubmedid: 18700732.
• Talele TT, McLaughlin ML. Molecular docking/dynamics studies of Aurora A kinase inhibitors. J Mol Graph Model. 2008 Jun;26(8):1213-1222. Pubmedid: 18096419.
• Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci U S A. 2007 May;104(18):7391-7396. Pubmedid: 17463090.
• Weiss S, McIntyre N, McLaughlin M, Merkler D. The development of molecular clamps as drugs. Drug Discov Today. 2006 Aug;11(17-18):819-824. Pubmedid: 16935750.
• Gennaccaro A, McLaughlin M, Quintero-Betancourt W, Huffman D, Rose J. Infectious Cryptosporidium parvum oocysts in final reclaimed effluent. Appl Environ Microbiol. 2003;69(8):4983-4984. Pubmedid: 12902296.
• McLaughlin M, Hunter D, Thomson C, Yool D, Kirkham D, Freer A, Griffiths I. Evidence for possible interactions between PLP and DM20 within the myelinsheath. Glia. 2002;39:31-36. Pubmedid: 12112373.
• Yool D, Montague P, McLaughlin M, McCulloch M, Edgar J, Nave K, DaviesRW, Griffiths I, McCallion A. Phenotypic analysis of mice deficient in the major myelin protein MOBP, and evidence for a novel Mobp isoform. Glia. 2002;39:256-267. Pubmedid: 12203392.
• Adams P, Chen Y, Ma K, Zagorski M, Sonnichsen F, McLaughlin M, BarkleyMD. Intramolecular quenching of tryptophan fluorescence by the peptide bond in cyclic hexapeptides. J Am Chem Soc. 2002;124(31):9278-9286. Pubmedid: 12149035.
• Sun T, Van Hoek A, Huang Y, Bouley R, McLaughlin M, Brown D. Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis bydominant-negative dynamin. Am J Physiol Renal Physiol. 2002;282:F998-1011. Pubmedid: 11997316.
• Yuan H, Takeuchi E, Taylor G, McLaughlin M, Brown D, Salant D. Nephrin dissociates from actin, and its expression is reduced in earlyexperimental membranous nephropathy. J Am Soc Nephrol. 2002;13:946-956. Pubmedid: 11912254.
• Hellberg M, McLaughlin M, Sharif N, DeSantis L, Dean T, Kyba E, Bishop J, Klimko P, Zinke P, Selliah R, Barnes G, DeFaller J, Kothe A, Landry T, SullivanE, Andrew R, Davis A, Silver L, Bergamini M, Robertson S, Weiner A, Sallee V. Identification and Characterization of the Ocular Hypotensive Efficacy ofTravoprost, a Potent and Selective FP Prostaglandin Receptor Agonist, andAL-6598, a DP Prostaglandin Receptor Agonist. Surv Ophthalmol. 2002;47 Suppl 1:S13-S13. Pubmedid: 12204698.
• Chun T, Justement J, Pandya P, Hallahan C, McLaughlin M, Liu S, EhlerLA, Kovacs C, Fauci A. Relationship between the size of the human immunodeficiency virus type 1 (HIV-1)reservoir in peripheral blood CD4+ T cells and CD4+:CD8+ T cell ratios inaviremic HIV-1-infected individuals receiving long-term highly activeantiretroviral therapy. J Infect Dis. 2002;185:1672-1676. Pubmedid: 12023777.
• Zhu Y, Xu G, Patel A, McLaughlin M, Silverman C, Knecht K, Sweitzer S, LiX, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney L, Hu E, Livi G, WolfB, Abdel-Meguid S, Rose G, Aurora R, Hensley P, Briggs M, Young P. Cloning, Expression, and Initial Characterization of a Novel Cytokine-like GeneFamily. Genomics. 2002;80:144-144. Pubmedid: 12160727.
• McLaughlin M, Hale R, Ellston D, Gaudet S, Lue R, Viel A. The distribution and function of alternatively spliced insertions in hDlg. J Biol Chem. 2002;277:6406-6412. Pubmedid: 11723125.
• Sodha M, McLaughlin M, Williams G, Dhillon S. Nurses' confidence and pharmacological knowledge: a study. Br J Community Nurs. 2002;7:309-315. Pubmedid: 12066065.
• Yokum T, Hammer R, McLaughlin M, Elzer P. Peptides with indirect in vivo activity against an intracellular pathogen: selective lysis of infected macrophages. J Pept Res. 2002;59(1):9-17. Pubmedid: 11906603.
• Fu Y, Hammarström LG, Miller TJ, Fronczek FR, McLaughlin ML, Hammer RP. Sterically hindered C(alpha, alpha)-disubstituted alpha-amino acids: synthesis from alpha-nitroacetate and incorporation into peptides. J Org Chem. 2001 Oct;66(21):7118-7124. Pubmedid: 11597239.
• Williamson S, McLaughlin M, Paul J. Interaction of the PhiHSIC virus with its host: lysogeny or pseudolysogeny. Appl Environ Microbiol. 2001;67(4):1682-1688. Pubmedid: 11282621.
• McDaniel L, Griffin D, Crespo-Gomez J, McLaughlin M, Paul J. Evaluation of marine bacterial lysogens for development of a marine prophage induction assay. Mar Biotechnol (Ny). 2001;3:528-535. Pubmedid: 14961325.