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Ling Zhang, MD

Where You Are:

Ling Zhang, MD

Pathology-Hematology

 
 

BOARD CERTIFICATION:
          •  Anatomic Pathology & Clinical Pathology - Pathology-Hematology

FELLOWSHIP:
          •  Cedars Sinai Medical Center - Hematopathology
          •  MD Anderson Cancer Center - Surgical Oncology and Experimental Therapeutics

RESIDENCY:
          •  University of Louisville - Anatomic and Clinical Pathology

MEDICAL SCHOOL:
          •  Fujian College of Traditional Chinese Medicine - MD

  • Zhang Y, Zhang L, Jin X, Zhao H, Hao X, Peker D, Wei S, Sokol L, Moscinski L. Bone marrow involvement as initial presentation of CD8 cytotoxic peripheral T-cell lymphoma with CD20 coexpression and relatively indolent clinical course. Leuk Lymphoma. 2013 May;54(5):1113-1116. Pubmedid: 23035635.

  • Duong VH, Lancet JE, Alrawi E, Al-Ali NH, Perkins J, Field T, Epling-Burnette PK, Zhang L, List AF, Komrokji RS. Outcome of azacitidine treatment in patients with therapy-related myeloid neoplasms with assessment of prognostic risk stratification models. Leuk Res. 2013 May;37(5):510-515. Pubmedid: 23332452.

  • Zhang S, Wu CC, Fecteau JF, Cui B, Chen L, Zhang L, Wu R, Rassenti L, Lao F, Weigand S, Kipps TJ. Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44. Proc Natl Acad Sci U S A. 2013 Apr;110(15):6127-6132. Pubmedid: 23530247.

  • Zhang L, Shao H. Primary cutaneous CD4 positive small/medium T-cell lymphoma with high proliferation index and CD30-positive large lymphoid cells. J Cutan Pathol. 2013 Apr. Pubmedid: 23672694.

  • Mishra A, Corrales-Yepez M, Ali NA, Kharfan-Dabaja M, Padron E, Zhang L, Epling-Burnette PK, Pinilla-Ibarz J, Lancet JE, List AF, Komrokji RS. Validation of the revised international prognostic scoring system in treated patients with myelodysplastic syndromes. Am J Hematol. 2013 Apr. Pubmedid: 23605934.

  • Duong VH, Jaglal MV, Zhang L, Kale V, Lancet JE, Komrokji RS, List AF. Phase II pilot study of oral dasatinib in patients with higher-risk myelodysplastic syndrome (MDS) who failed conventional therapy. Leuk Res. 2013 Mar;37(3):300-304. Pubmedid: 23273539.

  • Peker D, Quigley B, Qin D, Papenhausen P, Zhang L. Burkitt lymphoma arising from lymphoplasmacytic lymphoma following acquisition of MYC translocation and loss of the ETV6 tumor suppressor gene. Arch Pathol Lab Med. 2013 Jan;137(1):130-133. Pubmedid: 23276184.

  • Zhang L, Sotomayor EM, Papenhausen PR, Shao H, Moscinski LC, Sandin RL, Caceres G, Valenica H, Malafa M, List AF, Sokol L. Unusual concurrence of T-cell large granular lymphocytic leukemia with Franklin disease (gamma heavy chain disease) manifested with massive splenomegaly. Leuk Lymphoma. 2013 Jan;54(1):205-208. Pubmedid: 22694793.

  • Setoodeh R, Schwartz S, Papenhausen P, Zhang L, Sagatys EM, Moscinski LC, Shao H. Double-hit mantle cell lymphoma with MYC gene rearrangement or amplification: a report of four cases and review of the literature. Int J Clin Exp Pathol. 2013;6(2):155-167. Pubmedid: 23330001.

  • Komrokji RS, Corrales-Yepez M, Kharfan-Dabaja MA, Al Ali NH, Padron E, Rollison DE, Pinilla-Ibarz J, Zhang L, Epling-Burnette PK, Lancet JE, List AF. Hypoalbuminemia is an independent prognostic factor for overall survival in myelodysplastic syndromes. Am J Hematol. 2012 Nov;87(11):1006-1009. Pubmedid: 23090887.

  • Bello C, Zhang L, Naghashpour M. Follicular lymphoma: current management and future directions. Cancer Control. 2012 Jul;19(3):187-195. Pubmedid: 22710894.

  • Nair RR, Tolentino JH, Argilagos RF, Zhang L, Pinilla-Ibarz J, Hazlehurst LA. Potentiation of Nilotinib-mediated cell death in the context of the bone marrow microenvironment requires a promiscuous JAK inhibitor in CML. Leuk Res. 2012 Jun;36(6):756-763. Pubmedid: 22209738. Pmcid: PMC3331955.

  • Quigley B, Peker D, Zhang L. A composite small lymphocytic lymphoma and Hodgkin transformation presenting as acute appendicitis. Ann Hematol. 2012 May;91(5):801-802. Pubmedid: 21915619.

  • Sugimori C, Padron E, Caceres G, Shain K, Sokol L, Zhang L, Tiu R, O'Keefe CL, Afable M, Clemente M, Lee JM, Maciejewski JP, List AF, Epling-Burnette PK, Araten DJ. Paroxysmal nocturnal hemoglobinuria and concurrent JAK2(V617F) mutation. Blood Cancer J. 2012 Mar;2(3):e63. Pubmedid: 22829258. Pmcid: PMC3317526.

  • Sagatys EM, Zhang L. Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia. Cancer Control. 2012 Jan;19(1):18-25. Pubmedid: 22143059.

  • Mathew RA, Bennett JM, Liu JJ, Komrokji RS, Lancet JE, Naghashpour M, Messina JL, List AF, Moscinski LC, Zhang L. Cutaneous manifestations in CMML: Indication of disease acceleration or transformation to AML and review of the literature. Leuk Res. 2012 Jan;36(1):72-80. Pubmedid: 21782240.

  • Liu JJ, Zhang L, Ayala E, Field T, Ochoa-Bayona JL, Perez L, Bello CM, Chervenick PA, Bruno S, Cultrera JL, Baz RC, Kharfan-Dabaja MA, Raychaudhuri J, Sotomayor EM, Sokol L. Human immunodeficiency virus (HIV)-negative plasmablastic lymphoma: a single institutional experience and literature review. Leuk Res. 2011 Dec;35(12):1571-1577. Pubmedid: 21752466.

  • Lebovic D, Zhang L, Alsina M, Nishihori T, Shain KH, Sullivan D, Ochoa-Bayona JL, Kharfan-Dabaja MA, Baz R. Clinical outcomes of patients with plasma cell leukemia in the era of novel therapies and hematopoietic stem cell transplantation strategies: a single-institution experience. Clin Lymphoma Myeloma Leuk. 2011 Dec;11(6):507-511. Pubmedid: 21813352.

  • Zhang X, Bui MM, Caracciolo J, Field TL, Zhang L. Adult anaplastic large cell lymphoma involving the central nervous system: a rare clinical scenario. Ann Hematol. 2011 Jun;90(6):721-723. Pubmedid: 20838823.

  • Zhang L, Bennett JM, Zhang X, Moscinski L, Ibarz-Pinilla J, List AF, Komrokji R. Uncommon of the uncommon: low-grade myelodysplastic syndrome evolving into chronic myelogenous leukemia. J Clin Oncol. 2011 May;29(15):e434-e436. Pubmedid: 21149648.

  • Powers JJ, Dubovsky JA, Epling-Burnette PK, Moscinski L, Zhang L, Mustjoki S, Sotomayor EM, Pinilla-Ibarz JA. A molecular and functional analysis of large granular lymphocyte expansions in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors. Leuk Lymphoma. 2011 Apr;52(4):668-679. Pubmedid: 21271862.

  • Komrokji RS, Zhang L, Bennett JM. Myelodysplastic syndromes classification and risk stratification. Hematol Oncol Clin North Am. 2010 Apr;24(2):443-457. Pubmedid: 20359636.

  • Kawamata N, Zhang L, Ogawa S, Nannya Y, Dashti A, Lu D, Lim S, Schreck R, Koeffler HP. Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization. Leuk Res. 2009 Apr;33(4):569-571. Pubmedid: 18799215. Pmcid: PMC2762476.

  • Haritunians T, Gueller S, Zhang L, Badr R, Yin D, Xing H, Fung MC, Koeffler HP. Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells. Leuk Res. 2008 Sep;32(9):1366-1373. Pubmedid: 18405967.

  • Wong AK, Fang B, Zhang L, Guo X, Lee S, Schreck R. Loss of the Y chromosome: an age-related or clonal phenomenon in acute myelogenous leukemia/myelodysplastic syndrome?. Arch Pathol Lab Med. 2008 Aug;132(8):1329-1332. Pubmedid: 18684036.

  • Westfall DE, Zhang L, Song S, Lee S. Concurrent megakaryocytic and erythroid chronic myelogenous leukemia blast crisis. Arch Pathol Lab Med. 2008 Jun;132(6):1021-1025. Pubmedid: 18517263.

  • Zhang L, Talwalkar SS, Shaheen SP . A case of primary unilateral adrenal Burkitt-like large cell lymphoma presenting as adrenal insufficiency. Ann Diagn Pathol. 2007 Apr;11(2):127-131. Pubmedid: 17349573.

  • Zhang L, Whitis JG, Embry MB, Hollensead SC. A simplified algorithm for the laboratory detection of lupus anticoagulants: utilization of two automated integrated tests. Am J Clin Pathol. 2005 Dec;124(6):894-901. Pubmedid: 16416739.

  • Zhang L, Ray MB, Moore GD. An 82-year-old woman with a 25-cm abdominal mass. Arch Pathol Lab Med. 2005 Jul;129(7):e162-e164. Pubmedid: 15974827.

  • Zhang L, Hollensead S, Parker JC . Extensive aortic thromboembolism due to acquired hypercoagulable state: an autopsy case report. Arch Pathol Lab Med. 2005 Feb;129(2):247-250. Pubmedid: 15679433.

  • Zhang L, Snyder JW, Parker JC . Cerebral intraventricular mass due to cysticercosis: two cases reports. J Ky Med Assoc. 2004 May;102(5):215-218. Pubmedid: 15152447.

  • Donato NJ, Wu JY, Zhang L, Kantarjian H, Talpaz M. Down-regulation of interleukin-3/granulocyte-macrophage colony-stimulating factor receptor beta-chain in BCR-ABL(+) human leukemic cells: association with loss of cytokine-mediated Stat-5 activation and protection from apoptosis after BCR-ABL inhibition. Blood. 2001 May;97(9):2846-2853. Pubmedid: 11313280.

  • Pearson AS, Chiao P, Zhang L, Zhang W, Larry L, Katz RL, Evans DB, Abbruzzese JL. The detection of telomerase activity in patients with adenocarcinoma of the pancreas by fine needle aspiration. Int J Oncol. 2000 Aug;17(2):381-385. Pubmedid: 10891550.

  • Mujoo K, Zhang L, Klostergaard J, Donato NJ. Emergence of cisplatin-resistant cells from the OVCAR-3 ovarian carcinoma cel l line with p53 mutations, altered tumorigenicity, and increased apoptotic sensitivity to p53 gene replacement. Int J Gynecol Cancer. 2000 Mar;10(2):105-114. Pubmedid: 11240661.

  • Hunt KK, Fleming JB, Abramian A, Zhang L, Evans DB, Chiao PJ. Overexpression of the tumor suppressor gene Smad4/DPC4 induces p21waf1 expression and growth inhibition in human carcinoma cells. Cancer Res. 1998 Dec;58(24):5656-5661. Pubmedid: 9865717.

  • Grau AM, Zhang L, Wang W, Ruan S, Evans DB, Abbruzzese JL, Zhang W, Chiao PJ. Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells. Cancer Res. 1997 Sep;57(18):3929-3934. Pubmedid: 9307274.

  • Naghashpour M, Lancet J, Moscinski L, Zhang L. Mixed phenotype acute leukemia with t(11;19)(q23;p13.3)/ MLL-MLLT1(ENL), B/T-lymphoid type: A first case report. Am J Hematol. 2010 Jun;85(6):451-454. Pubmedid: 20513125.

  • Trimaldi J, Carballido EM, Bowers JW, Anguiano AL, Zhang ZJ, Shah BD, Bruno S, List AF, Moscinski LC, Grady T, Agosti SJ, Kang L, Zhang L. B-Lymphoblastic Leukemia/Lymphoma Associated with t(8;13)(p11;q12)/ ZMYM2 (ZNF198)-FGFR1 : Rare Case and Review of the Literature. Acta Haematol. 2013 Apr;130(3):127-134. Pubmedid: 23594707.

  • Zhang L, Alsabeh R, Mecucci C, La Starza R, Gorello P, Lee S, Lill M, Schreck R. Rare t(1;11)(q23;p15) in therapy-related myelodysplastic syndrome evolving into acute myelomonocytic leukemia: a case report and review of the literature. Cancer Genet Cytogenet. 2007 Oct;178(1):42-48. Pubmedid: 17889707.

Actively involved in clinical service and teaching responsibilities, mainly for hematopathology fellows and dedicate in the studies related to new marker development in helping diagnoses or predicting disease prognosis of myeloid malignancies including myelodysplastic syndromes, myeloproliferative disorders and myeloid leukemia as well as T-cell lymphoproliferative disorder.

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